The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors (PPARs)
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چکیده
منابع مشابه
Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis
BACKGROUND Peroxisome proliferator-activated receptor (PPAR) alpha, betadelta and gamma are nuclear receptors activated by fatty acid metabolites. An anti-inflammatory role for these receptors in airway inflammation has been suggested. METHODS Nasal biopsies were obtained from 10 healthy volunteers and 10 patients with symptomatic allergic rhinitis. Nasal polyps were obtained from 22 patients...
متن کاملPeroxisome Proliferator-Activated Receptors (PPARs): Choreographers of Metabolic Gene Transcription
Nuclear receptors are ligand-activated transcription factors that regulate gene expression in response to small lipophilic compounds such as testosterone [androgen receptor (AR)], oxysterols [liver X receptor (LXR)], estrogen (ER), xenobiotics [pregnane X receptor (PXR)], retinoic acid (RAR), thyroid hormone (TR), bile acids [farnesoid X receptor (FXR)] and vitamin D (VDR). The peroxisome proli...
متن کاملPeroxisome Proliferator-activated Receptors
Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...
متن کاملActivation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters.
Administration of phthalates is known to cause toxicity and liver cancer in rodents through the activation of peroxisome proliferator-activated receptors (PPARs), and the monoesters appear to be the active metabolites that function as ligands of PPARs. There is evidence that PPARs exhibit significant species differences in response to ligand activation. In this study, the activation of mouse an...
متن کاملExpression of the Peroxisome Proliferator-Activated Receptors (PPARs) in the Hepatic Stellate Cells
Email: Takeya Sato* [email protected]; Mitsuru Sato [email protected]; Mitsutaka Miura [email protected]; Nobuyo Higashi [email protected]; Da-Ren Wang [email protected]; Shinsuke Suzuki [email protected]; Katsuyuki Imai [email protected]; Naosuke Kojima [email protected]; Haruki Senoo [email protected] * Corresponding author
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2002
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.9.233